Drug intelligence / Profile preview

fluticasone + salmeterol + prednisolone

Development stage
Unknown
Lead developer
GSK
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation, Oral
01

Overview

This is a combination of three drugs—fluticasone, salmeterol, and prednisolone. Fluticasone is a synthetic corticosteroid with potent anti-inflammatory activity, commonly used to reduce inflammation in the airways. Salmeterol is a long-acting beta2-adrenergic agonist (LABA) that acts as a bronchodilator by relaxing airway smooth muscle and improving airflow. Prednisolone is an oral corticosteroid with systemic anti-inflammatory and immunosuppressive effects. While fluticasone and salmeterol are frequently combined in inhaled formulations for maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD), the addition of prednisolone (typically administered orally) would be used for acute exacerbations or severe inflammatory conditions requiring both local (inhaled) and systemic steroid therapy. This triple combination does not correspond to any single approved product or fixed-dose formulation but may be prescribed together in clinical practice for patients needing both maintenance therapy (fluticasone/salmeterol) and short-term systemic steroids (prednisolone).

02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)

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