fluticasone propionate + azelastine hydrochloride (oral)

This combination therapy consists of an intranasal corticosteroid (INCS) and an oral antihistamine (OAH). Specifically, it involves the concurrent use of **fluticasone propionate** nasal spray and **azelastine hydrochloride** tablets. Fluticasone propionate is a synthetic glucocorticoid that acts as a potent anti-inflammatory agent by binding to the glucocorticoid receptor, thereby reducing the production of inflammatory mediators in the nasal mucosa. Azelastine hydrochloride is a second-generation H1-receptor antagonist that systemically blocks the action of histamine, a primary mediator of allergic responses. This specific regimen was evaluated in a Phase 4 clinical trial conducted by the **China-Japan Union Hospital** to compare its efficacy against a fixed-dose intranasal combination (INCS + INAH) in patients with moderate to severe allergic rhinitis.

Brand names

FushuliangKedumin

Other names

INCS + OAHintranasal corticosteroids + oral antihistaminesfluticasone propionate nasal spray + azelastine hydrochloride tablets