Drug intelligence / Profile preview

fluticasone propionate + phenylephrine

Development stage
Unknown
Lead developer
Shayana Farm
Modality
Small Molecules
Administration
Intranasal
01

Overview

Rhinitease-P is a combination nasal spray developed by Shayana Farm for the management of allergic rhinitis and associated nasal congestion. It is a fixed-dose formulation containing fluticasone propionate, a synthetic corticosteroid, and phenylephrine hydrochloride, a sympathomimetic decongestant. Fluticasone propionate acts as a potent glucocorticoid receptor agonist, reducing airway inflammation by inhibiting the release of various inflammatory mediators and cytokines. Phenylephrine hydrochloride acts as a selective alpha-1 adrenergic receptor agonist, inducing vasoconstriction of the nasal mucosa to provide rapid relief from nasal blockage. The product is administered as a metered nasal spray, offering a dual-action approach to both the underlying inflammatory cause and the immediate symptoms of rhinitis.

Brand names
Rhinitease-P
02

Targets

GR (Glucocorticoid receptor)ADRA1A (α1A)

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