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fluticasone propionate + salmeterol (Teva Pharmaceutical)
- Development stage
- Unknown
- Lead developer
- Teva Pharmaceutical Industries
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
AirDuo (marketed as AirDuo RespiClick and AirDuo Digihaler) is an FDA-approved fixed-dose combination of fluticasone propionate and salmeterol xinafoate. Developed by Teva and its subsidiary Actavis Laboratories, it is indicated for the maintenance treatment of asthma in patients aged 12 years and older. Fluticasone propionate is an inhaled corticosteroid (ICS) that targets the glucocorticoid receptor to suppress inflammatory processes in the lungs, while salmeterol is a long-acting beta2-adrenergic agonist (LABA) that stimulates beta-2 adrenergic receptors to relax airway smooth muscle and improve lung function. The drug is delivered via a breath-activated dry powder inhaler and is administered twice daily. It is not indicated for the relief of acute bronchospasm.
- Brand names
- AdoairAdvairAdvair DiskusAdvair HFAAirDuoAirDuo DigihalerAirDuo RespiClickSeretideVianiWixela Inhub
- Other names
- fluticasone propionate + salmeterolfluticasone propionate + salmeterol xinafoatefluticasone propionate/salmeterol xinafoatefluticasone/salmeterolsalmeterol xinafoate + fluticasone propionate
02
Targets
Kv1 (Voltage-gated potassium channel subfamily A)ADRB1 (β1)ADRB2 (β2)GR (Glucocorticoid receptor)ADRB3 (β3)
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