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FMP014 + ALFQ
- Development stage
- Unknown
- Lead developer
- Walter Reed Army Institute of Research
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes, Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular
01
Overview
FMP014 + ALFQ is an experimental pre-erythrocytic malaria vaccine candidate developed by the Walter Reed Army Institute of Research (WRAIR) in collaboration with Alpha-O Peptides. The vaccine consists of FMP014, a recombinant self-assembling protein nanoparticle (SAPN) that forms an icosahedral structure of 60 identical monomer chains. Each monomer displays Plasmodium falciparum circumsporozoite protein (PfCSP) epitopes, including CD4+ and CD8+ T-cell epitopes, universal TH epitopes, portions of the α-TSR domain, and six repeats of the NANP motif. FMP014 is formulated with ALFQ (Army Liposome Formulation containing QS-21), a potent liposome-based adjuvant designed to enhance both humoral and cellular immune responses. The vaccine is intended to prevent Plasmodium falciparum malaria by targeting the sporozoite stage before it infects hepatocytes.
- Other names
- FMP014 + ALFQFMP014/ALFQPfCSP-SAPN
02
Targets
CSP (Circumsporozoite protein)
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