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FOLFOX + cediranib
- Development stage
- Phase 3
- Lead developer
- AstraZeneca
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Intravenous, Oral
01
Overview
FOLFOX + cediranib is a combination regimen consisting of the chemotherapy protocol FOLFOX (folinic acid [leucovorin], fluorouracil [5-FU], and oxaliplatin) plus the small molecule tyrosine kinase inhibitor cediranib. - **FOLFOX** is a standard chemotherapy regimen for colorectal cancer and other solid tumors. It works by combining agents that disrupt DNA synthesis (fluorouracil), enhance cytotoxicity (folinic acid), and cause DNA crosslinking leading to apoptosis (oxaliplatin). - **Cediranib** is an oral inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, blocking angiogenesis required for tumor growth. Cediranib also inhibits platelet-derived growth factor receptors and c-Kit. The addition of cediranib to FOLFOX aims to combine direct cytotoxic effects with antiangiogenic therapy for enhanced antitumor activity[3][6][10].
- Brand names
- RECENTIN (cediranib)FOLFOX (regimen name, not a brand but used in clinical context)
- Other names
- FOLFOXfolinic acid + fluorouracil + oxaliplatin + cediranibleucovorin calcium + 5-fluorouracil + oxaliplatin + cediranib
02
Targets
PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)DNA interstrand cross-link
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