FOLFOX + curcumin

FOLFOX + curcumin is an investigational combination therapy consisting of the standard chemotherapy regimen FOLFOX (folinic acid, fluorouracil, and oxaliplatin) plus the dietary supplement curcumin. - **FOLFOX** is a well-established chemotherapy protocol primarily used for colorectal cancer. It combines three agents: - Folinic acid (leucovorin), which enhances the effectiveness of fluorouracil. - Fluorouracil (5-FU), a pyrimidine analog that inhibits thymidylate synthase, disrupting DNA synthesis in rapidly dividing cells. - Oxaliplatin, a platinum-based agent that forms DNA crosslinks and induces apoptosis in cancer cells[1][2][4]. - **Curcumin** is a polyphenolic compound derived from turmeric with anti-inflammatory and potential anticancer properties. It modulates multiple molecular targets involved in cell proliferation, apoptosis, angiogenesis, and metastasis. The rationale for combining FOLFOX with curcumin is based on preclinical evidence suggesting that curcumin may enhance chemosensitivity to standard regimens like FOLFOX by modulating drug resistance pathways and reducing inflammation. This combination remains experimental; clinical trials are ongoing or proposed to evaluate its safety and efficacy.

Other names

folinic acid + fluorouracil + oxaliplatin + curcumin