FOLFOX-6 + Vigil

FOLFOX-6 + Vigil is a combination therapy consisting of the FOLFOX-6 chemotherapy regimen and Vigil, an autologous tumor cell immunotherapy. **FOLFOX-6** is a specific protocol of the FOLFOX regimen, which includes three drugs: folinic acid (leucovorin), fluorouracil (5-FU), and oxaliplatin. This combination acts as cytotoxic chemotherapy by interfering with DNA synthesis and function in rapidly dividing cancer cells. It is most commonly used for colorectal cancer and administered intravenously in 14-day cycles[1][2][4]. **Vigil** (also known as gemogenovatucel-T) is an autologous tumor cell vaccine genetically modified to express GM-CSF and knock down furin expression, thereby enhancing immune recognition of tumor antigens while reducing local immunosuppression. It aims to stimulate the patient’s immune system to recognize and attack their own cancer cells.