FOLFOXIRI + delta-tocotrienol

FOLFOXIRI + delta-tocotrienol is an investigational combination therapy consisting of the established FOLFOXIRI chemotherapy regimen and the dietary supplement delta-tocotrienol. - **FOLFOXIRI** is a four-drug chemotherapy regimen used primarily for advanced or metastatic colorectal cancer. It includes: - Folinic acid (leucovorin): a vitamin B derivative that enhances the efficacy and reduces side effects of fluorouracil. - Fluorouracil (5-FU): a pyrimidine analog antimetabolite that inhibits DNA synthesis in rapidly dividing cells. - Oxaliplatin: a platinum-based agent that disrupts DNA repair and synthesis. - Irinotecan: a topoisomerase I inhibitor, preventing DNA uncoiling and replication[2][6]. - **Delta-tocotrienol** is one of the isoforms of vitamin E, classified as a dietary supplement with antioxidant properties. It has been studied for potential anticancer effects but is not an approved pharmaceutical agent. The combination aims to leverage both cytotoxic chemotherapy (FOLFOXIRI) and possible adjunctive or synergistic effects from delta-tocotrienol, though this specific pairing remains experimental.