folic acid + cyanocobalamin + pyridoxine

This B-vitamin complex is a therapeutic formulation consisting of high doses of folic acid (Vitamin B9), cyanocobalamin (Vitamin B12), and pyridoxine (Vitamin B6). Developed by researchers at the Universität des Saarlandes, it was specifically investigated for its potential to mitigate cognitive decline in the elderly. The primary mechanism of action involves the reduction of plasma homocysteine levels, as elevated homocysteine is a known biomarker associated with age-related cognitive impairment and dementia. The intervention studied in clinical trial NCT01095211 utilized a combination of oral daily doses (5 mg folic acid, 1 mg cyanocobalamin, and 40 mg vitamin B6) supplemented by subcutaneous cyanocobalamin injections to ensure optimal bioavailability and metabolic correction.

Other names

B-vitamin complexB-vitamins