folic acid + proguanil + Jobelyn

This is a combination regimen consisting of three components: - **Folic acid** (a synthetic form of vitamin B9) is essential for DNA synthesis and repair, red blood cell formation, and prevention of anemia. - **Proguanil** (marketed as Paludrine) is an antimalarial agent that acts as a prodrug; its active metabolite cycloguanil inhibits the malaria parasite's dihydrofolate reductase, disrupting folate metabolism in the parasite and preventing its replication[4][6][9]. - **Jobelyn** is a proprietary extract derived from Sorghum bicolor. It has been studied for its antioxidant properties and potential to improve hematological parameters such as hemoglobin levels. It may also have anti-inflammatory effects[1][3][7]. This combination has been used in clinical studies involving patients with sickle cell anemia to support hematopoiesis, prevent malaria (especially in endemic regions), and provide antioxidant benefits[1][7]. Folic acid supplementation is particularly important when using proguanil due to possible depletion of body stores by the drug[4]. Jobelyn may further contribute to improved hemoglobin levels and immune function through its phytochemical content[3].

Brand names

PaludrineJobelyn

Other names

folic acid + Paludrine + Jobelyn