Drug intelligence / Profile preview

follicle-stimulating hormone + gonadorelin + chorionic gonadotropin + menotropin

Development stage
Unknown
Lead developer
Ferring Pharmaceuticals
Modality
Recombinant Proteins and Enzymes
Administration
Subcutaneous, Intramuscular, Intravenous
01

Overview

This is a combination formulation containing four active hormonal ingredients used in reproductive medicine: - **follicle-stimulating hormone (FSH)**: a pituitary-derived gonadotropin that stimulates ovarian follicle growth in females and spermatogenesis in males. - **gonadorelin**: a synthetic form of gonadotropin-releasing hormone (GnRH), which stimulates the anterior pituitary to release FSH and luteinizing hormone (LH), thereby initiating the reproductive hormone cascade[1][2][7]. - **chorionic gonadotropin (hCG)**: a placental hormone that mimics LH and can directly stimulate the gonads, commonly used to trigger ovulation and support fertility treatments[8][10]. - **menotropin**: a purified preparation containing both FSH and LH, traditionally sourced from urine of postmenopausal women, used to induce ovulation and spermatogenesis. **Mechanism of action**: This combination acts in a coordinated manner to stimulate ovarian and testicular function at multiple biochemical points—mimicking and augmenting physiological reproductive hormone cascades. Such combinations may be used in complex fertility protocols such as controlled ovarian hyperstimulation in assisted reproductive technology or for certain cases of male hypogonadism. Each hormone has a distinct but related effect on the hypothalamic-pituitary-gonadal axis.

02

Targets

FSHR (Follicle-stimulating hormone receptor)LHCGR (Luteinizing hormone/choriogonadotropin receptor)GnRHR (Gonadotropin-releasing hormone receptor)

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