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Drug intelligence / Profile preview
follitropin alfa + choriogonadotropin alfa + gonadotropin-releasing hormone antagonist
- Development stage
- Unknown
- Lead developer
- Merck KGaA
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
This is a combination regimen of three hormonal agents commonly used in assisted reproductive technology (ART), notably in vitro fertilization (IVF) protocols. **Follitropin alfa** is a recombinant form of follicle-stimulating hormone (FSH), which stimulates ovarian follicular growth. **Choriogonadotropin alfa** is a recombinant human chorionic gonadotropin (hCG) used to induce final oocyte maturation. A **gonadotropin-releasing hormone antagonist** (GnRH antagonist) prevents premature luteinizing hormone (LH) surges during ovarian stimulation. The combination allows controlled ovarian hyperstimulation, followed by oocyte maturation, optimizing synchronization of ovulation and egg retrieval[1][3][6][7][8][9].
02
Targets
FSHR (Follicle-stimulating hormone receptor)GnRHR (Gonadotropin-releasing hormone receptor)LHCGR (Luteinizing hormone/choriogonadotropin receptor)
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