Drug intelligence / Profile preview

follitropin alfa + fructose + tetracycline hydrochloride + cetrorelix acetate

Development stage
Unknown
Lead developer
EMD Serono
Modality
Recombinant Proteins and Enzymes, Peptides, Small Molecules
Administration
Subcutaneous, Topical
01

Overview

This combination represents a clinical protocol used in assisted reproductive technology (ART), specifically for in vitro fertilization and embryo transfer (IVF-ET) in patients with decreased ovarian reserve (DOR). It consists of **follitropin alfa** (a recombinant follicle-stimulating hormone used for controlled ovarian stimulation), **cetrorelix acetate** (a GnRH antagonist used to prevent premature ovulation), and a vaginal preparation containing **tetracycline hydrochloride** and **fructose** (used for local disinfection and maintaining the vaginal environment prior to procedures). This specific regimen is being evaluated by the Peking University Third Hospital in Phase 3 trials to determine the efficacy of adding sequential traditional Chinese medicine (TCM) formulas to standard IVF-ET protocols to improve pregnancy outcomes. The protocol aims to optimize follicular development and endometrial receptivity while minimizing the risk of infection and premature luteinization.

Other names
follitropin alfa + fructose + tetyacycline hydrochloride + cetrorelix acetate
02

Targets

GnRHR (Gonadotropin-releasing hormone receptor)Bacterial RibosomeFSHR (Follicle-stimulating hormone receptor)

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