follitropin alfa + lutropin alfa (Merck & Co.)

Follicle stimulating hormone (FSH) + luteinizing hormone (LH) refers to a combination of two gonadotropins used in assisted reproductive technology (ART) to stimulate ovarian follicle development. This combination mimics the endogenous action of the two pituitary gonadotropins: FSH, which promotes the recruitment and growth of multiple follicles, and LH, which supports follicular steroidogenesis and final maturation. It is available as recombinant formulations (e.g., **follitropin alfa + lutropin alfa**) or urinary-derived human menopausal gonadotropins (**menotropins**). In clinical practice, such as in the real-world 'FOLLITROPIN' study (NCT04854707), recombinant FSH biosimilars like **Primapur** (follitropin alpha, developed by **IVFarma**) are often used either alone or in combination with LH-containing preparations to optimize ovarian response, particularly in patients with profound gonadotropin deficiency or poor ovarian reserve. The combination is typically administered via subcutaneous or intramuscular injection.

Brand names

Merional

Other names

follicle stimulating hormone + luteinizing hormonemenotropinshuman menopausal gonadotropinhMGr-hFSH + r-hLH