Foreskin keratinocyte (neonatal)

Foreskin keratinocyte (neonatal) refers to cultured epidermal cells derived from the foreskins of newborn males. These cells are used as a cell therapy to accelerate wound closure and healing, particularly in chronic wounds and burns. The product is classified as a biologic and is used in cell transplant therapies. Foreskin keratinocytes form the main component of the skin's outer layer and play a critical role in barrier function and tissue repair. They are often delivered on a matrix such as bovine collagen or type I collagen sponge for application to wounds. Products like Gintuit utilize these cells for regenerative purposes, while similar products such as Apligraf combine them with fibroblasts for enhanced wound healing effects[1][5]. The mechanism involves providing living allogeneic skin cells that promote re-epithelialization, secrete growth factors, and support host tissue regeneration.

Brand names

Gintuit

Other names

normal human epidermal keratinocytes (NHEK)neonatal foreskin keratinocytesNFKs