Drug intelligence / Profile preview

frankincense essential oil + boswellic acid

Development stage
Preclinical
Lead developer
Sabinsa
Modality
Small Molecules
Administration
Oral, Topical, Inhalation
01

Overview

Frankincense essential oil + boswellic acid is a combination product derived from resin of Boswellia trees, primarily containing frankincense essential oil and its major active triterpenoid components known as boswellic acids (including β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-acetyl-11-keto-β-boswellic acid)[5]. The combination is recognized for its anti-inflammatory, analgesic, immunomodulatory, antimicrobial, and some anticancer properties[1][3][5][6]. Mechanistically, boswellic acids primarily inhibit key inflammatory pathways (5-lipoxygenase, cyclooxygenase-2, proinflammatory cytokines), reduce leukotriene synthesis, suppress matrix metalloproteinases, and in cancer contexts, regulate apoptosis and cell cycle through modulation of NF-κB, VEGFR2, and AMPK/mTOR pathways[3][6]. Frankincense essential oil is typically used topically, by inhalation, or as a flavor for oral health, while boswellic acids are mainly consumed orally in standardized extract form. The combination may be found in dietary supplements or multi-ingredient products for inflammatory diseases, arthritis, asthma, gut disorders, or general immune support[1][2][4][6].

Other names
frankincense oil + boswellic acidfrankincense oil and boswellic acidfrankincense + boswellic acid
02

Targets

ALOX12 (Arachidonate 12-lipoxygenase, 12S type)AMPK (Adenosine monophosphate–activated protein kinase)NEMO (NF-κB essential modulator)IL1B (Interleukin-1 beta)TOP2A (DNA topoisomerase II)TOP1 (DNA Topoisomerase I)GLUT1 (Glucose transporter 1)VEGFR2 (Vascular endothelial growth factor receptor 2)ELANE (Human Neutrophil Elastase)

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