freeze-dried mamushi antivenom, equine

Mamushi antivenom (specifically Freeze-dried Mamushi Equine Antivenom) is a horse-derived polyclonal antibody preparation developed and manufactured by KM Biologics (formerly Kaketsuken) for the treatment of envenomation caused by the Japanese mamushi (*Gloydius blomhoffii*), the most common venomous snake in Japan. The antivenom is produced by purifying immunoglobulin from the serum of horses immunized with mamushi venom or toxoid. It works by binding to and neutralizing the diverse toxic components of the venom, which include phospholipase A2, metalloproteinases, and hemorrhagins, thereby preventing severe complications such as local tissue necrosis, rhabdomyolysis, acute renal failure, and disseminated intravascular coagulation (DIC). It is administered parenterally (intravenously, intramuscularly, or subcutaneously) as soon as possible after a bite, particularly in patients presenting with moderate to severe envenomation symptoms.

Brand names

Freeze-dried Mamushi Equine Antivenom Injection 6000 units KMBFreeze-dried Mamushi Equine Antivenom for Injection 6000 units KMBMamushi Antivenom Kaketsuken乾燥まむし抗毒素「KMB」乾燥まむし抗毒素「化血研」

Other names

Agkistrodon blomhoffii antivenomAgkistrodon halys antivenomCSTRI-MAMUmamushi antivenommamushi antivenom, equinemamushi equine antivenomまむし抗毒素乾燥まむしウマ抗毒素