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fructose-1,6-diphosphate
- Development stage
- Unknown
- Lead developer
- Cypros Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Fructose-1,6-diphosphate (FDP) is an endogenous glycolytic intermediate being investigated as a metabolic antidote for cardiac glycoside poisoning, particularly that induced by yellow oleander (*Thevetia peruviana*). In the context of cardiac glycoside toxicity, Na-K-ATPase is inhibited, leading to intracellular calcium overload and life-threatening arrhythmias. FDP is hypothesized to bypass inhibited steps in glycolysis, thereby restoring ATP production and counteracting the downstream effects of Na-K-ATPase inhibition. It is being developed by the South Asian Clinical Toxicology Research Collaboration (SACTRC) and the University of Peradeniya as a cost-effective alternative to digoxin-specific antibody fragments in resource-limited settings. Clinical evaluation has progressed to Phase II randomized trials in Sri Lanka.
- Brand names
- Esafosfina
- Other names
- fructose 1,6-bisphosphateD-fructose 1,6-bisphosphateHarden-Young ester
02
Targets
ATP1A (Sodium/potassium-transporting ATPase)
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