Drug intelligence / Profile preview

fruquintinib + adebrelimab + oxaliplatin + capecitabine

Development stage
Phase 2
Lead developer
Takeda
Administration
Oral, Intravenous
01

Overview

This entry describes the combination of fruquintinib, adebrelimab, oxaliplatin, and capecitabine. Based on the provided search results: * Fruquintinib is described as a highly selective and potent oral inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2, and 3, approved for metastatic colorectal cancer. * Oxaliplatin and capecitabine (CAPOX/XELOX) is described as a chemotherapy combination used for colorectal cancer treatment. * Adebrelimab is not mentioned in the search results. * The specific four-drug combination of fruquintinib, adebrelimab, oxaliplatin, and capecitabine is not mentioned in the search results. Therefore, comprehensive information about this particular combination cannot be provided based solely on the given text. The combination may be experimental or in early clinical trials not covered by the provided information.

02

Targets

DNACD274 (Programmed cell death protein 1 ligand 1)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)

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