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Drug intelligence / Profile preview
fruquintinib + candonilimab + tegafur + gimeracil + oteracil potassium
- Development stage
- Phase 2
- Lead developer
- HUTCHMED
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
This is a combination of multiple drugs: **Fruquintinib** is a highly selective oral tyrosine kinase inhibitor that targets VEGFR-1, VEGFR-2, and VEGFR-3, inhibiting angiogenesis and tumor blood vessel maturation. It has weak inhibitory effects on RET, FGFR1, and c-KIT kinases. **Candonilimab** is not described in the provided search results. **Tegafur-gimeracil-oteracil potassium (S-1)** is a combination oral fluoropyrimidine anticancer drug: - Tegafur is a prodrug of 5-fluorouracil (5-FU) with good oral absorption - Gimeracil inhibits dihydropyrimidine dehydrogenase to prevent 5-FU catabolism - Oteracil potassium inhibits phosphorylation of 5-FU, reducing gastrointestinal toxicity
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)DPYD (Dihydropyrimidine dehydrogenase)OPRT (Orotidine 5'-phosphate decarboxylase)PDCD1 (Programmed cell death protein 1 receptor)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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