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FT-002a is an orally bioavailable peptide therapeutic developed by AecorBio, designed to target Iron Responsive Element Binding Protein 2 (IREB2) and modulate the intracellular labile iron pool (LIP). By disrupting iron homeostasis, FT-002a aims to exploit the iron dependency of advanced cancer cells, particularly in castration-resistant prostate cancer (CRPC) and platinum-resistant ovarian cancer. The candidate is currently in the IND-enabling stage of development, focusing on inducing anti-tumor effects through the depletion or modulation of iron availability within the tumor microenvironment.
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