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fulvestrant + 177Lu-DOTATATE
- Development stage
- Phase 1
- Lead developer
- University of Chicago Comprehensive Cancer Center
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Gamma Emitters → Radiopharmaceuticals, Small Molecules, Peptides
- Administration
- Intramuscular, Intravenous
01
Overview
fulvestrant + 177Lu-DOTATATE is a combination therapy being investigated for the treatment of advanced pancreatic neuroendocrine tumors (pNETs). The regimen consists of fulvestrant, a selective estrogen receptor degrader (SERD) that binds to and promotes the degradation of estrogen receptors, and 177Lu-DOTATATE, a radiolabeled somatostatin analog. 177Lu-DOTATATE functions as a peptide receptor radionuclide therapy (PRRT), specifically targeting somatostatin receptors (primarily SSTR2) overexpressed on the surface of neuroendocrine tumor cells to deliver cytotoxic beta radiation from the Lutetium-177 isotope directly to the cancer cells. This combination, evaluated in clinical trials led by the University of Chicago, explores the potential for hormonal modulation to enhance the therapeutic profile of PRRT in patients with advanced pNETs.
- Other names
- Fulvestrant and 177Lu-DOTATATE177Lu-DOTA-TATE and FulvestrantFulvestrant + Lutathera
02
Targets
ER (Estrogen receptor)SSTR2 (Somatostatin receptor type 2)DNA
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