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fulvestrant + abemaciclib
- Development stage
- Phase 4
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral, Intramuscular
01
Overview
Fulvestrant + abemaciclib is a combination therapy used for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced or metastatic breast cancer in women with disease progression after endocrine therapy. Abemaciclib is a CDK4/6 inhibitor with greater relative potency for cyclin D1/CDK4 compared with cyclin D3/CDK6. Fulvestrant is an estrogen receptor antagonist. The combination has demonstrated significant improvement in progression-free survival compared to fulvestrant alone.
02
Targets
CDK4 (Cyclin-dependent kinase 4)CDK6 (Cyclin-dependent kinase 6)ESR1 (ERα)ESR2 (ERβ)
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