Drug intelligence / Profile preview

fulvestrant + ipatasertib + palbociclib

Development stage: Unknown
Lead developer: Roche
Modality: Small Molecules
Administration: Oral, Intramuscular

Overview

A triple combination therapy consisting of fulvestrant (a selective estrogen receptor downregulator), ipatasertib (an AKT inhibitor), and palbociclib (a CDK4/6 inhibitor). This combination targets multiple pathways involved in hormone receptor-positive breast cancer growth and endocrine resistance: estrogen receptor signaling, PI3K/AKT/mTOR pathway, and cell cycle regulation through CDK4/6 inhibition.

Targets

ESR1 (ERα)CDK4 (Cyclin-dependent kinase 4)AKT2 (Rac-beta serine/threonine-protein kinase)ESR2 (ERβ)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CDK6 (Cyclin-dependent kinase 6)

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