furosemide + albumin

furosemide + albumin is a combination therapy being evaluated for the treatment of fluid overload in critically ill patients, specifically within the context of the FANTASTIC clinical trial (Furosemide vs Furosemide + Albumin in Critically Ill Patients) led by Jose J Zaragoza, MD MSc. Furosemide is a loop diuretic that inhibits the sodium-potassium-chloride symporter (NKCC2) in the thick ascending limb of the loop of Henle, promoting the excretion of water and electrolytes. Albumin is a plasma protein that increases intravascular oncotic pressure, which is intended to facilitate the movement of fluid from the interstitial space into the vasculature and potentially improve the delivery of furosemide to the renal tubules. This combination is particularly aimed at patients who may be resistant to diuretic monotherapy due to hypoalbuminemia or other factors associated with critical illness.

Other names

furosemide + albumin-Jose J Zaragoza, MD MSc-fluid overloadfurosemide plus albuminalbumin plus furosemideFANTASTIC trial intervention