furosemide + amiloride

Furosemide + amiloride is a **combination drug** containing the loop diuretic furosemide and the potassium-sparing diuretic amiloride. This dual therapy is used primarily for the treatment of **hypertension (high blood pressure)** and **oedema (fluid retention)**, particularly when potassium conservation is important, such as in heart failure, liver disease, or nephrotic syndrome[1][3][7][9]. - **Furosemide** acts by inhibiting the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending loop of Henle, which blocks reabsorption of sodium and chloride and promotes diuresis[5]. - **Amiloride** inhibits epithelial sodium channels (ENaC) in the distal nephron, leading to reduced sodium reabsorption and conservation of potassium[2][6][8]. The combination is designed to clear excess fluid while counteracting furosemide-induced potassium loss[1][3].

Brand names

FrumilFrumil LSAmilaxCo-amilofruse

Other names

co-amilofrusefurosemide + amiloridefrusemide + amiloride