fusidic acid + hydrocortisone

Fusidic acid + hydrocortisone is a topical combination drug containing the antibiotic fusidic acid and the mild corticosteroid hydrocortisone or hydrocortisone acetate. It is primarily indicated for the treatment of mild to moderately severe skin infections, notably atopic dermatitis or eczema with secondary infection by *Staphylococcus aureus*[2][3][5][9]. Fusidic acid inhibits bacterial protein synthesis by interfering with amino acid transfer on bacterial ribosomes, targeting Gram-positive bacteria such as *Staphylococcus aureus*[2][3]. Hydrocortisone acts as an anti-inflammatory, anti-pruritic, and vasoconstrictor agent; it reduces swelling, redness, and itching through inhibition of inflammatory mediator synthesis (mainly via induction of phospholipase A2 inhibitor proteins that prevent arachidonic acid release)[2][3][5]. The combination was developed to both address bacterial eradication and inflammation in cases where both are present, and it is more effective than either ingredient alone when staphylococcal infection is present[2]. The drug should be used short-term, as prolonged topical antibiotic or corticosteroid use may result in resistance, masking of infection, or other adverse effects[2][3].

Brand names

Fucidin HFuson HFuseal HHosol FFusibid HCortisoft FFusidott HFudiwin-HBacticort HFusirol H

Other names

fusidic acid + hydrocortisone acetatehydrocortisone + fusidic acid