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Fuzheng Kang'ai Decoction (Guangdong Provincial Hospital of Traditional Chinese Medicine)
- Development stage
- Unknown
- Lead developer
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Fuzheng Kang'ai Decoction is a Traditional Chinese Medicine (TCM) herbal formula developed by the Guangdong Provincial Hospital of Chinese Medicine. It is designed to "strengthen the body's resistance" (Fuzheng) and exert anti-tumor effects (Kang'ai). In clinical research, it is specifically investigated for the treatment of advanced non-small cell lung cancer (NSCLC), particularly in patients classified under the "phlegm-damp" syndrome in TCM. The decoction is often used as an adjuvant therapy alongside immune checkpoint inhibitors, such as PD-1 inhibitors, to enhance efficacy and potentially mitigate side effects. Its mechanism likely involves immunomodulation and regulation of the tumor microenvironment, though specific molecular targets for the complex mixture are not typically defined in a single-target pharmacological sense.
- Other names
- Fuzheng Kang'ai Tang
02
Targets
BCL-2 (BCL-2 family)STAT3 (Signal Transducer and Activator of Transcription 3)PRKCA (Protein kinase C alpha)CCNA2 (Cyclin A2)AMPK (Adenosine monophosphate–activated protein kinase)
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