gabapentin + thiamine + cobalamin

Gabapentin + thiamine + cobalamin is a combination drug used primarily for the treatment of neuropathic pain, diabetic neuropathy, nerve damage, and vitamin B deficiencies associated with nerve pain[1][2][4]. **Gabapentin**, a small molecule anticonvulsant, acts as an alpha-2-delta ligand, modulating calcium channel activity and diminishing excitatory neurotransmitter release to reduce pain signaling[2][3][4]. **Thiamine (vitamin B1)** enhances carbohydrate metabolism, suppresses protein glycation and oxidative stress, and improves neuronal energy status[4]. **Cobalamin (vitamin B12, as either cyanocobalamin or methylcobalamin)** supports myelin synthesis, neuronal regeneration, and modulates pain pathways via sensory neuron inhibition and neurotransmitter regulation[4]. B vitamins synergize with gabapentin to enhance pain relief and reduce adverse effects, allowing lower doses of gabapentin for similar efficacy[3][4].

Brand names

Gavindo

Other names

gabapentin + vitamin B1 + vitamin B12gabapentin + thiamine + cyanocobalamingabapentin + benfotiamine + cyanocobalamin