gadolinium (Bayer)

Gadolinium is a paramagnetic contrast agent primarily used in magnetic resonance imaging (MRI) to enhance the visibility of internal body structures. In the specific context of the clinical trial led by Li Nguyen for cervical dystonia, gadolinium is utilized as a tracer to evaluate the distribution, localization, and persistence of fluids injected into the tissue. The study compares the delivery of injections via the ASIS (Automated Subdermal Injection System) device, which targets the subdermal space and fascia, against traditional intramuscular injections. By measuring the persistent percentage of gadolinium on MRI at 6, 12, and 24 hours, the trial aims to demonstrate that subdermal delivery can prolong the presence of therapeutic agents like onabotulinumtoxinA (Botox) at the site of action while minimizing systemic spread and adverse reactions.

Brand names

MagnevistGadavistDotaremOmniscanProHanceMultiHanceAblavarEovist

Other names

gadolinium contrast mediumgadolinium-based contrast agentGBCA