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gadolinium + dexamethasone
- Development stage
- Unknown
- Lead developer
- University of Missouri-Columbia
- Modality
- Small Molecules
- Administration
- Epidural
01
Overview
This refers to a specific injectate mixture used in a clinical research study conducted at the University of Missouri-Columbia to evaluate the dispersal patterns of cervical epidural steroid injections. The formulation consists of a gadolinium-based contrast agent (GBCA), such as gadodiamide (Omniscan) or gadobutrol (Gadavist), mixed with the corticosteroid dexamethasone and saline. In this context, gadolinium serves as a paramagnetic contrast agent for magnetic resonance imaging (MRI), allowing researchers to visualize and track the dispersal of the injectate within the epidural space. The primary therapeutic component is dexamethasone, a synthetic glucocorticoid used to treat inflammation associated with cervical radiculopathy. The gadolinium component is used strictly as an imaging tracer to validate the localization and spread of the medication and does not contribute to the therapeutic relief of radicular pain.
- Brand names
- OmniscanGadavist
- Other names
- Injection with GadoliniumGadolinium Dispersal in Cervical Epidural Steroid Injectionsgadolinium-University of Missouri-Columbia-cervical radiculopathy
02
Targets
GR (Glucocorticoid receptor)
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