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gadolinium + indocyanine green
- Development stage
- Preclinical
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
DM-Dual-Gd-ICG is a dual-mode contrast agent designed for multimodal imaging, combining gadolinium (Gd) for magnetic resonance (MR) imaging and indocyanine green (ICG) for near-infrared (NIR) fluorescence imaging. This agent is specifically developed to improve the management of ovarian cancer by enabling high-resolution pre-surgical staging and planning via MR, followed by real-time intraoperative guidance using NIR fluorescence to assist in the complete surgical resection of peritoneal tumors. Preclinical studies in mouse models (Hey-A8 and OVCAR3) have demonstrated that the agent significantly enhances tumor visualization in the peritoneal cavity, showing increased signal-to-noise ratios on MR and distinct fluorescence during open-abdomen surgery.
- Other names
- dual-mode dual-gadolinium indocyanine green contrast agentGd-ICGgadolinium-indocyanine green complex
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