Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
galantamine + memantine
- Development stage
- Phase 4
- Lead developer
- Johnson & Johnson
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Galantamine + memantine is a combination of two small molecule drugs used primarily for the treatment of cognitive impairments, most notably in Alzheimer's disease. Galantamine acts as an acetylcholinesterase inhibitor and also serves as a positive allosteric modulator at α4β2 and α7 nicotinic acetylcholine receptors, enhancing cholinergic neurotransmission. Memantine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, modulating glutamatergic neurotransmission to prevent excitotoxicity. The combination targets both cholinergic and glutamatergic pathways implicated in neurodegenerative diseases, providing synergistic neuroprotective effects. This dual approach aims to address multiple pathological mechanisms underlying cognitive decline[1][2][5].
- Brand names
- Galto Plus
- Other names
- Galto Plusgalantamine/memantine
02
Targets
AcetylcholinesteraseNMDAR (Glutamate receptor ionotropic, NMDA)α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)CHRNA7 (α7 nicotinic receptor)
Beyond the preview
Go deeper on galantamine + memantine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on galantamine + memantine.