Drug intelligence / Profile preview

galicaftor + navocaftor + ABBV-576

Development stage: Unknown
Lead developer: AbbVie
Modality: Small Molecules
Administration: Oral

Overview

**galicaftor + navocaftor + ABBV-576** is a combination drug under investigation as a triple CFTR (cystic fibrosis transmembrane conductance regulator) modulator therapy for the treatment of **cystic fibrosis (CF)**, specifically in patients who are homozygous or heterozygous for the F508del mutation. Each component is believed to target different defects in the CFTR protein, aiming to restore its function in people with CF. The drug is administered orally and is being evaluated for its safety and efficacy in both adult and pediatric CF populations in Phase 2 clinical studies[1][2][3][7][8][9].

Other names: galicaftor/navocaftor/ABBV-576

Targets

CFTR (Cystic fibrosis transmembrane conductance regulator)

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