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Gardasil + CYD Dengue Vaccine
- Development stage
- Approved
- Lead developer
- Sanofi Pasteur
- Modality
- Recombinant Proteins and Enzymes, Live Vector Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
This drug entry refers to the concomitant or sequential administration of two distinct vaccines: the quadrivalent human papillomavirus (HPV) vaccine (Gardasil) and the tetravalent dengue vaccine (CYD-TDV, marketed as Dengvaxia). Gardasil is a recombinant vaccine composed of virus-like particles (VLPs) of the L1 protein from HPV types 6, 11, 16, and 18, designed to prevent cervical, vulvar, vaginal, and anal cancers, as well as genital warts. Dengvaxia is a live-attenuated tetravalent vaccine developed by Sanofi Pasteur using a yellow fever virus 17D backbone to express the pre-membrane and envelope proteins of the four dengue virus serotypes (DENV-1, 2, 3, and 4). The combination was evaluated in Phase 3 clinical trials to assess the safety and immunogenicity of co-administering these vaccines to adolescents, specifically to ensure that the immune response to one vaccine does not interfere with the other.
- Brand names
- GardasilDengvaxia
- Other names
- Human Papillomavirus Quadrivalent [Types 6, 11, 16, and 18] Vaccine, RecombinantTetravalent Dengue VaccineCYD-TDV + Gardasil
02
Targets
Dengue virus type 2 pre-membrane and envelope proteinsHPV11 L1Dengue virus type 3 premembrane and envelope proteinsHPV18 L1Dengue virus type 1 premembrane and envelope proteinsDengue virus type 4 precursor membrane and envelope proteinsHPV (Human papillomavirus)HPV6 L1 (Human papillomavirus type 6 major capsid protein L1)
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