Drug intelligence / Profile preview

garden balsam + platycladus orientalis leaves decoction

Development stage
Preclinical
Lead developer
Jiaxing Hospital of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Topical
01

Overview

Garden balsam + platycladus orientalis leaves decoction is a traditional Chinese medicine (TCM) preparation utilized by the Jiaxing Hospital of Chinese Medicine for the treatment of androgenic alopecia (AGA). The decoction is composed of the aerial parts of *Impatiens balsamina* (garden balsam) and the leaves of *Platycladus orientalis* (oriental arborvitae). It is typically administered as a topical wash or soak to the scalp. The therapeutic effect is attributed to the synergistic action of phytochemicals such as naphthoquinones (e.g., lawsone) from garden balsam and flavonoids (e.g., quercitrin) from *Platycladus orientalis*. These constituents are thought to inhibit the activity of 5-alpha reductase, thereby reducing the conversion of testosterone to dihydrotestosterone (DHT), a primary driver of hair follicle miniaturization in AGA. Additionally, the preparation exhibits anti-inflammatory and antioxidant properties that support hair follicle health and stimulate the transition of follicles from the telogen to the anagen growth phase.

Other names
Impatiens balsamina and Platycladus orientalis decoctionFengxianhua Cebaiye Tang
02

Targets

SRD5A (Steroid 5-alpha-reductase)AR (Adrenergic receptors)

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