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gefitinib + metformin
- Development stage
- Discontinued
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of gefitinib, an EGFR tyrosine kinase inhibitor, and metformin, a biguanide antidiabetic drug. This combination has been investigated primarily for non-small cell lung cancer (NSCLC), particularly in patients with EGFR mutations, with the aim of overcoming resistance to EGFR-TKIs. The combination works by targeting both the EGFR signaling pathway (via gefitinib) and the IGF-1R signaling pathway (via metformin).
- Brand names
- IressaGlucophageFortametGlumetzaRiomet
- Other names
- metformin hydrochloridegefitinib
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)IGF-1R (Insulin-like growth factor 1 receptor)
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