gelatin tannate + oral rehydration solution + zinc

A fixed-dose **combination therapy** consisting of **gelatin tannate**, **oral rehydration solution (ORS)**, and **zinc** administered orally, typically for the management of **acute gastroenteritis and diarrhea in children**. - **Gelatin tannate** is a complex of tannic acid and gelatin, which forms a protective biofilm on the intestinal mucosa. It acts locally as a mucoprotectant, exhibits astringent and anti-inflammatory effects, and may impede the growth of certain enteric pathogens and block proinflammatory mediators. The precise molecular targets are not fully characterized but it works by creating a barrier and limiting mucosal inflammation[1][2]. - **Oral rehydration solution** provides balanced electrolytes and glucose to rehydrate and correct fluid and electrolyte loss due to diarrhea. - **Zinc** is included as supplementation; it is essential for immune function and epithelial repair, and supplementation has been shown to reduce the **duration and severity of diarrhea**, especially in children with malnutrition or zinc deficiency[1]. This triple combination is intended for oral use in pediatric patients, with the goal of reducing duration and severity of diarrhea and correcting dehydration—but randomized controlled trials show **no statistically significant benefit** of adding gelatin tannate to standard ORS and zinc in well-nourished children, though some benefit may exist in certain subpopulations[1][3][2].