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gemcitabine + carboplatin
- Development stage
- Unknown
- Lead developer
- Eli Lilly
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Gemcitabine + carboplatin is a combination chemotherapy regimen used primarily to treat various cancers including advanced ovarian cancer, non-small cell lung cancer (NSCLC), and bladder cancer. Both drugs are administered intravenously in cycles of 21 days. Gemcitabine is a nucleoside analog antimetabolite that inhibits DNA synthesis by blocking the progression of cells through the G1/S-phase boundary and interfering with ribonucleotide reductase and DNA polymerization. Carboplatin is a platinum-based compound that causes crosslinking of DNA strands, leading to apoptosis in rapidly dividing cells such as cancer cells. The combination exploits different mechanisms to maximize cytotoxicity against tumor cells.
- Brand names
- ParaplatinGemzarInfugem
- Other names
- GemCarbo
02
Targets
DNADNA polymerase familyRNR (Ribonucleotide reductase)
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