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gemcitabine + cisplatin + docetaxel
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen comprising gemcitabine, cisplatin, and docetaxel, studied as a first-line treatment for locally advanced or metastatic non-small cell lung cancer (NSCLC). This regimen utilizes three distinct mechanisms of action: gemcitabine acts as a nucleoside analog that inhibits DNA synthesis and ribonucleotide reductase; cisplatin is a platinum-based agent that creates DNA cross-links to induce apoptosis; and docetaxel is a taxane that stabilizes microtubules, leading to mitotic arrest. Sanofi sponsored clinical research, specifically a Phase II trial, to evaluate the efficacy and safety of sequential or concurrent administration of these agents compared to doublet therapies in advanced lung cancer patients.
- Brand names
- Taxotere
- Other names
- Gemcitabine/Cisplatin/DocetaxelDocetaxel/Gemcitabine/Cisplatin
02
Targets
TUBB (Tubulin (alpha and beta subunits))DNARNR (Ribonucleotide reductase)
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