Drug intelligence / Profile preview

gemcitabine + topotecan

Development stage
Phase 3
Lead developer
Eli Lilly
Modality
Small Molecules
Administration
Intravenous
01

Overview

A chemotherapy combination regimen consisting of gemcitabine and topotecan administered intravenously. This combination has been studied primarily for the treatment of recurrent ovarian cancer, particularly in patients who have relapsed after platinum/taxane-based first-line chemotherapy. It has shown modest activity with manageable toxicity profiles, even in heavily pretreated patients.

Other names
gemcitabine + topotecantopotecan and gemcitabinegemcitabine and topotecan
02

Targets

DNA polymerase familyTOP1 (DNA Topoisomerase I)

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