gentamicin + EDTA

**Gentamicin + EDTA** is an investigational combination of the aminoglycoside antibiotic gentamicin and the chelating agent ethylenediaminetetraacetic acid (EDTA). Gentamicin functions by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit, leading to bactericidal effects against a wide range of Gram-negative and some Gram-positive organisms. EDTA acts as a metal chelator that can disrupt bacterial biofilms and cell walls, increase membrane permeability, and, in combination with gentamicin, suppress antibiotic resistance mechanisms such as efflux pumps. The combination is primarily studied for use against multidrug-resistant Gram-negative bacterial infections and for eradication of bacterial biofilms, especially in catheter-related infections. Preclinical and in vitro studies show that EDTA significantly enhances the antibacterial and antibiofilm efficacy of gentamicin against resistant bacterial strains by potentiating gentamicin’s activity and reducing resistance[1][2].

Other names

gentamicin and EDTAgentamicin-EDTA combination