Drug intelligence / Profile preview

ginkgo biloba + methylprednisolone

Development stage
Preclinical
Lead developer
Ergon Pharmaceuticals
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous, Intramuscular
01

Overview

This is a combination of Ginkgo biloba, a plant-derived dietary supplement with vasoregulatory and antioxidant properties, and methylprednisolone, a synthetic glucocorticoid corticosteroid used for its potent anti-inflammatory and immunosuppressive effects. Ginkgo biloba is thought to improve blood flow, reduce oxidative stress, and modulate platelet-activating factor. Methylprednisolone acts by binding to the glucocorticoid receptor to suppress inflammation and immune responses. The combination has been studied in clinical settings (primarily with other corticosteroids such as prednisone) for conditions like sudden sensorineural hearing loss, where it may improve hemorheological parameters (blood viscosity), immune cell profiles (T cell subsets), and overall symptom improvement compared to steroid monotherapy[2][5][9]. There are known pharmacodynamic interactions between these agents; co-administration may increase the risk or severity of adverse effects[3].

Other names
ginkgo biloba and methylprednisoloneginkgo biloba extract plus methylprednisolone
02

Targets

GR (Glucocorticoid receptor)PTAFR (Platelet-activating factor receptor)

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