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Drug intelligence / Profile preview
ginseng + regorafenib
- Development stage
- Unknown
- Lead developer
- Bayer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Ginseng + regorafenib is a combination therapy being investigated for its potential synergistic effects in cancer treatment. Regorafenib is a kinase inhibitor that targets multiple kinases involved in tumor growth and angiogenesis, while ginseng is an herbal supplement with potential anti-cancer and supportive care properties. The combination has shown synergistic inhibitory effects on cancer cell growth in preclinical studies, particularly in hepatocellular carcinoma (HCC). Clinical research is also exploring whether ginseng can help reduce fatigue and improve adherence to regorafenib treatment in colorectal cancer patients.
02
Targets
FGFR1 (Fibroblast growth factor receptor 1)PDGFRB (Platelet-derived growth factor receptor beta)TEK (Tie2)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)HIF1A (Hypoxia-inducible factor 1-alpha)
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