ginsenoside 20(S)-Rh2

**ginsenoside 20(S)-Rh2** is a dammarane-type triterpenoid saponin and a bioactive component of Panax ginseng and Panax notoginseng. It is present in very low amounts in red ginseng and is mainly recognized for its potent antitumor properties, including apoptosis induction, inhibition of cancer cell proliferation, metastasis, and modulation of tumor cell energy metabolism. Its proposed mechanisms include direct binding and inhibition of Annexin A2 (reducing NF-κB signaling and survival gene expression), inhibition of PI3K/Akt/mTOR and STAT3/c-Myc pathways, enhancement of caspase activation, and modulation of death receptor 5 (DR5) activity. The compound sensitizes cancer cells to TRAIL-induced apoptosis and may enhance efficacy of anticancer agents. Ginsenoside 20(S)-Rh2 also possesses hepatoprotective, cardioprotective, bone density conservation, and antibacterial properties, including the capacity to increase intracellular antibiotic accumulation via inhibition of P-gp and BCRP efflux transporters[1][2][3][4][5][6][8].

Other names

ginsenoside Rh2G-Rh2G-Rh-2G-Rh 220S-ginsenoside Rh220(S)-ginsenoside-Rh2