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giredestrant + ribociclib
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of giredestrant, a next-generation oral selective estrogen receptor antagonist and degrader (SERD), and ribociclib, a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i). This combination is being investigated for the treatment of estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer, particularly in patients who have developed resistance to prior endocrine therapy.
02
Targets
CDK6 (Cyclin-dependent kinase 6)ER (Estrogen receptor)CDK4 (Cyclin-dependent kinase 4)
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