glimepiride + ketotifen

Glimepiride + ketotifen is a combination of two small molecule drugs, glimepiride and ketotifen. Glimepiride is a sulfonylurea antidiabetic agent that stimulates insulin secretion from pancreatic beta cells, thereby lowering blood glucose levels. Ketotifen is an antihistamine and mast cell stabilizer that acts as a non-competitive antagonist of the histamine H1 receptor and inhibits the release of inflammatory mediators from mast cells. This combination has been studied for its potential to improve glycemic control and reduce inflammation in obese patients with type 2 diabetes mellitus (T2DM), based on evidence suggesting that mast cell stabilization may help mitigate obesity-induced insulin resistance[2]. The co-administration of these agents has shown beneficial effects on glycemic parameters and inflammatory biomarkers in clinical studies[2].