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Drug intelligence / Profile preview
glipizide + metformin + insulin
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Oral, Subcutaneous, Intravenous, Inhalation
01
Overview
This is a combination of three diabetes medications: glipizide (a sulfonylurea), metformin (a biguanide), and insulin. While glipizide and metformin are available as a fixed-dose combination under brand names like Metaglip, adding insulin would typically be done as a separate medication. This triple therapy approach might be used when dual oral therapy doesn't provide adequate glycemic control in type 2 diabetes. Glipizide stimulates insulin secretion from the pancreas, metformin improves insulin sensitivity and reduces hepatic glucose production, while exogenous insulin supplements the body's natural insulin.
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)INSR (Insulin receptor)ND1 (Mitochondrial electron transport chain complex I)SUR1 (Sulfonylurea receptor 1)
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