glp-1-(9,36)amide

GLP-1-(9,36)amide is a major metabolite of the incretin hormone glucagon-like peptide 1 (GLP‑1)-(7‑36)amide, generated by cleavage with dipeptidyl peptidase-IV. Unlike its parent compound, which is a potent agonist at the GLP‑1 receptor and stimulates insulin secretion, GLP‑1-(9,36)amide acts primarily as an antagonist at the human pancreatic GLP‑1 receptor. It has very low affinity for this receptor and exhibits weak insulinotropic activity. However, it potently inhibits hepatic glucose production and may have additional biological effects such as antioxidant properties and cardiovascular protection. Some studies suggest it can modulate neuronal plasticity in the hippocampus. Its physiological role is still being elucidated; it does not appear to cause significant antagonism when administered subcutaneously due to its low binding affinity[1][2][3][4][5][6].

Other names

glucagon-like peptide 1 (9-36) amide